离子液体在经皮给药系统中的应用研究进展

Research progress in the application of ionic liquids in transdermal drug delivery system

离子液体(ionic liquids,ILs)是一类在室温或接近室温条件下呈液态的盐。由于其具有易于制备、稳定性好、溶解能力强和结构可调等优点,在生物医学特别是经皮给药方面得到了广泛的研究。ILs可以改善药物溶解度、促进药物经皮渗透、提高药物疗效、解决药物经皮递送存在的问题。本文综述了ILs的分类、合成方法以及ILs在经皮给药中的应用,并归纳了基于ILs的经皮给药制剂,以期为ILs在经皮给药中的深入研究和发展提供借鉴。

Ionic liquids(ILs)are a class of salts that appear liquid form at or near room temperature.They are widely used in biomedicine,especially in transdermal drug delivery,because of their simple preparation process,high stability,good solubility and flexible structure.ILs can improve drug solubility,promote transdermal penetration,improve the efficacy of drugs,and solve the problems existing in the transdermal drug delivery.This article reviewed the classification,synthesis methods and its application in transdermal drug delivery.The IL⁃based transdermal preparation was also summarized,in order to provide reference for further research and development of ILs in transdermal drug delivery.