白癜风新药研发的挑战与展望

Research and development of new vitiligo drugs:challenges and prospects

白癜风是一种难治性色素脱失性皮肤病,严重影响患者的容貌与心理。目前白癜风的发病机制包括遗传、氧化应激、自身免疫、环境因素等,其治疗手段包括系统应用糖皮质激素、局部应用糖皮质激素或钙调磷酸酶抑制剂、光疗、黑素细胞移植手术等。在此,本文回顾了既往白癜风常用的治疗药物并总结白癜风治疗药物新进展,新的小分子靶向药物的出现如Janus活化激酶(JAK)抑制剂巴瑞替尼等给白癜风的治疗带来新希望。

Vitiligo is a kind of refractory depigmentation skin disease,which seriously affects the appearance and psychology of patients.At present,the pathogenesis of vitiligo includes heredity,oxidative stress,autoimmunity and environmental factors.The treatment includes systematic application of glucocorticoid,local application of glucocorticoid or calcineurin inhibitor,phototherapy and melanocyte transplantation.In this article,we reviewed the commonly used therapeutic drugs for vitiligo in the past and summarized the new progress of therapeutic drugs for the treatment of vitiligo.The emergence of new small⁃molecule targeted drugs,such as Janus kinase inhibitor baricitinib,has brought hope for vitiligo.