抗病毒药物和急性肾损伤

Antiviral drugs and acute kidney injury

抗病毒药物是临床常用药,可通过多种机制导致急性肾损伤,包括肾脏低灌注、直接肾小管毒性、晶体肾病和血栓性微血管病等。新型冠状病毒感染(COVID-19)使抗病毒药物相关肾损伤获得了广泛的临床关注。本文回顾抗病毒药物在COVID-19治疗中的表现及其对肾脏的影响,总结了抗病毒药物相关急性肾损伤的临床表现和病理机制。

Antiviral drugs are commonly used in clinical practice, and may lead to acute kidney injury through a variety of mechanisms, including renal hypoperfusion, direct renal tubular toxicity, crystal nephropathy, and thrombotic microangiopathy, etc. The pandemic of COVID-19 has brought antiviral drug-associated kidney injury to extensive clinical focus. This article reviewed the performances of antiviral drugs in COVID-19 treatment and their effect on the kidney, and summarized the clinical manifestations and pathological mechanisms of antiviral drug-associated acute kidney injury.