四川省2022年0-11岁健康儿童水痘-带状疱疹病毒抗体水平调查

Varicella-zoster virus antibody levels among healthy children aged 0-11 years in Sichuan province,2022

目的了解四川省健康儿童水痘-带状疱疹病毒(Varicella-zoster virus,VZV)抗体水平。方法采用多阶段分层抽样方法在四川省10个县(市、区)选取0-11岁健康儿童开展问卷调查和采集血清标本,采用酶联免疫吸附试验检测VZV IgG抗体,分析抗体阳性率和几何平均浓度(Geometric mean concentration,GMC)。结果在1772名0-11岁调查儿童中,VZV抗体总阳性率和GMC分别为40.80%和70.73 mIU/mL。<1岁、1-2岁、3-5岁、6-11岁儿童抗体阳性率分别为14.55%、40.49%、51.70%、56.31%。0剂次、1剂次、2剂次水痘减毒活疫苗(Varicella attenuated live vaccine,VarV)免疫史儿童抗体阳性率分别为17.82%、46.51%、73.35%,其中1剂次免疫后<1年、3年、≥6年分别为39.45%、30.43%、51.56%,2剂次免疫后分别为77.12%、67.65%、58.82%。结论四川省0-11岁儿童VZV抗体水平总体较低;建议适龄儿童接种2剂次VarV,在第1剂接种3年后完成第2剂接种。

Objective To determine the antibody levels of varicella-zoster virus(VZV)in healthy children of Sichuan province.Methods We used a multi-stage stratified sampling method to select healthy children aged 0-11 years from 10 counties/districts of Sichuan for a questionnaire-based survey and serum sample collection.We tested sera for VZV IgG antibody using enzyme-linked immunosorbent assay and calculated positivity rates and geometric mean concentrations(GMC).Results Among 1772 children,the VZV IgG antibody positivity rate was 40.80%and the GMC was 70.73 mIU/mL.Antibody positivity rates for<1-,1-2-,3-5-,and 6-11-year-olds were 14.55%,40.49%,51.70%,and 56.31%;for 0,1,and 2 dose(s)of varicella attenuated live vaccine(VarV),positivity rates were 17.82%,46.51%,and 73.35%;for<1,3,and≥6 years after 1 dose of VarV,positivity rates were 39.45%,30.43%,and 51.56%;and for<1,3,and≥6 years after 2 doses of VarV,positivity rates were 77.12%,67.65%,and 58.82%.Conclusions The VZV antibody levels were generally low among 0-11-year-old children in Sichuan.We recommend a 2-dose VarV vaccination schedule for age-eligible children,with doses 3 years apart.