囊性肾细胞癌患者的临床特征及生存分析研究

Clinical characteristics and survival analysis of patients with cystic renal cell carcinoma

目的评估囊性肾细胞癌患者的临床特征并进行生存分析。方法选取SEER数据库中囊性肾细胞癌患者的临床数据, 检索时间为2004年到2019年, 记录患者的临床特征, 并利用Kaplan-Meier法进行生存分析。结果共纳入285例有完整临床资料的患者, 且经组织学均确诊为囊性肾细胞癌, 肾根治性切除术和肾部分切除术是主要的手术类型, 术后发生癌症特异性死亡10例(3.51%)。患者第1、5、10年的癌症特异性生存率分别为99.30%、96.85%、96.49%。结论与常见的肾透明细胞癌相比, 囊性肾细胞癌患者具有更低的临床分期, 更低比例的肿瘤进展和远处转移, 具有良好的预后和极低的疾病特异性死亡率, 但高组织学分级患者可能更容易发生肿瘤进展、复发和癌症特异性死亡, 建议接受更积极的治疗和监测。

Objective To evaluate the clinical characteristics and survival of patients with cystic renal cell carcinoma.Methods Clinical data of clear cell papillary renal cells between 2004 and 2019 was analyzed,to describe the clinical characterization of the patients,and the survival of the patients was analyzed using the Kaplan-Meier method.Results A total of 285 patients with complete clinical data were included,and cystic renal cell carcinoma was confirmed by histology.Radical nephrectomy and partial nephrectomy were the main types of surgery,and 10 patients(3.51%)died of cancer after surgery.The first,fifth and tenth year cancer specific survival rates were 99.30%,96.85%and 96.49%,respectively.ConclusionssCompared with common clear cell renal carcinoma,patients with cystic renal cell carcinoma have lower clinical stage,lower proportion of tumor progression and distant metastasis,good prognosis,and very low disease-specific mortality,but patients with high histological grade may be more prone to tumor progression,recurrence,and cancer-specific death,and more aggressive treatment and monitoring are recommended.