原发性玻璃体视网膜淋巴瘤的诊断研究进展

Research progress in the diagnosis of primary vitreoretinal lymphoma

原发性玻璃体视网膜淋巴瘤(PVRL)是最常见的眼内淋巴瘤,是原发性中枢神经系统淋巴瘤(PCNSL)的一种亚型,临床表现类似葡萄膜炎,是一种罕见的预后不良的眼内恶性肿瘤。细胞病理学检查是确诊PVRL的金标准,此外针对肿瘤细胞的克隆性检测及细胞因子等辅助检查目前已得到应用,近几年一些新的分子生物标志物和检测技术也逐渐发展起来。应结合PVRL的临床表现、细胞学检查、免疫学检测及分子生物学的检测结果综合判断,优化患者的诊断方案。本文就原发性玻璃体视网膜淋巴瘤的诊断研究进展进行综述。

Primary vitreoretinal lymphoma(PVRL),the most prevalent intraocular lymphoma,is a subtype of primary central nervous system lymphoma(PCNSL)that often clinically mimics uveitis.It is a rare intraocular malignancy characterized by a dismal prognosis.The gold standard for PVRL diagnosis remains cytopathological examination.Additionally,auxiliary tests,such as clonal detection of tumor cells and cytokine analysis,have been employed.Moreover,recent years have witnessed the gradual development of novel molecular biomarkers and detection techniques.To optimize diagnostic strategies for PVRL patients,a comprehensive approach that integrates clinical manifestations,cytological examination,immunological assessment,and molecular biology analysis is indispensable.This article provides a comprehensive review of recent advancements in the diagnosis of primary vitreoretinal lymphoma.