急性冠脉综合征痰瘀互结证与血尿酸、血脂、HCY及hs-CRP的关系

Relationship between intermingled phlegm and blood stasis syndrome and blood uric acid,blood lipid,HCY and hs-CRP in acute coronary syndrome

目的:研究不同中医证型急性冠脉综合征(ACS)患者血尿酸(UA)、血脂、同型半胱氨酸(HCY)及超敏C反应蛋白(hs-CRP)水平的关系。方法:将127例ACS患者按照中医辨证分为痰瘀互结证和非痰瘀互结证,比较两组患者UA、血脂、HCY及hs-CRP水平,并分析这些指标之间的相关性。结果:127例ACS患者中,痰瘀互结证占68.5%(87/127),非痰瘀互结证占31.5%(40/127)。痰瘀互结证患者UA、HCY、hs-CRP、总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)水平显著高于非痰瘀互结证(P<0.01,P<0.05)。UA与HCY、hs-CRP呈正相关(P<0.01,P<0.05),hs-CRP与TC、LDL-C呈正相关(P<0.05)。结论:ACS痰瘀互结证患者的UA、HCY、hs-CRP、血脂水平更高,表明这些指标与ACS痰瘀互结证具有相关性。ACS痰瘀互结证较别的证型具有更高程度的炎症损害和脂代谢异常。

Objective:To study the relationship between acute coronary syndrome(ACS)with different traditional Chinese medicine(TCM)syndromes and the levels of blood uric acid(UA),blood lipid,homocysteine(HCY)and hypersensitive C-reactive protein(hs-CRP).Methods:According to traditional Chinese medicine syndrome differentiation,127 patients with ACS were divided into intermingled phlegm and blood stasis syndrome and non-intermingled phlegm and blood stasis syndrome.The levels of UA,blood lipid,HCY and hs-CRP in the two groups were compared,and the correlation of each index was analyzed.Results:Among the 127 patients,the intermingled phlegm and blood stasis syndrome accounted for 68.5%(87/127),and the non-intermingled phlegm and blood stasis syndrome accounted for 31.5%(40/127).The levels of UA,HCY,hs-CRP,total cholesterol(TC)and low density lipoprotein cholesterol(LDL-C)in the intermingled phlegm and blood stasis syndrome group were significantly higher than those in the non-intermingled phlegm and blood stasis syndrome group(P<0.01,P<0.05).UA was positively correlated with HCY and hs-CRP(P<0.01,P<0.05),and hs-CRP was positively correlated with TC and LDL-C(P<0.05).Conclusion:The levels of UA,HCY,hs-CRP and blood lipid in ACS patients with intermingled phlegm and blood stasis syndrome are higher,which indicates that these indexes are related to ACS with intermingled phlegm and blood stasis syndrome.The intermingled phlegm and blood stasis syndrome of ACS has a higher degree of inflammatory damage and abnormal lipid metabolism compared to other syndrome types.