肿瘤相关成纤维细胞异质性及其在放射治疗中的调控作用

Heterogeneity of cancer-associated fibroblasts and regulating roles in cancer radiotherapy

肿瘤相关成纤维细胞(CAF)是肿瘤微环境(TME)中重要且丰富的基质细胞群,是抗肿瘤治疗的有效靶点。CAF具有高度的异质性和可塑性,在肿瘤发生发展、免疫逃逸及治疗抵抗中发挥重要作用。放射治疗是恶性肿瘤的基本治疗手段之一,可通过多种机制重塑TME。CAF在放射后发生一系列表型功能变化,与TME中多种细胞相互作用,通过促进肿瘤细胞增殖、调节免疫、促进血管再生、重塑细胞外基质、代谢重编程等多种途径促进放射抵抗和免疫排斥,进而影响放疗效果。靶向CAF的治疗策略与放疗有机结合可提高抗肿瘤效果,改善预后。本文就CAF在肿瘤放射治疗中的研究进展做一综述。

Cancer-associated fibroblasts(CAF)represent a crucial and abundant group of stromal cells in the tumor microenvironment(TME)and are effective targets for anti-tumor therapy.CAFs exhibit high heterogeneity and plasticity,which play a pivotal role in tumor initiation,progression,immune evasion,and therapy resistance.Radiotherapy(RT)is a fundamental treatment modality for malignant tumors that can reshape the TME through various mechanisms.Following RT,CAFs undergo a series of phenotypic changes and interact with multiple cells in the TME,promoting radioresistance and immune evasion through multiple pathways,such as enhancing tumor cell proliferation,modulating immune response,inducing angiogenesis,remodeling extracellular matrix,and reprogramming metabolism,etc.,thereby affecting therapeutic effect.Targeting CAFs in combination with RT can improve anti-tumor efficacy and prognosis.In this article,research progress in CAFs in tumor RT was reviewed.