瓜蒌皮注射液“从痰论治,痰瘀同调”治疗冠心病理论探析

Theory of Treating Coronary Heart Disease by Trichosanthes Peel Injection from“Phlegm and Modulating Phlegm-Stasis”

痰浊痹阻是冠心病的主要病机之一,痰、瘀同源互化,互为因果,共同参与冠心病的病理进程。瓜蒌皮注射液被广泛应用于冠心病的临床治疗,具有缓解症状,改善预后等作用。然而,目前其相应的中医理论基础及科学内涵有待进一步完善阐明。本文针对冠心病痰浊痹阻的病机,提出瓜蒌皮注射液“从痰论治,痰瘀同调”的治疗理念,其作用机制可能与舒张冠状动脉,保护内皮细胞,调节血脂和血液流变性,抑制血小板聚集,稳定斑块等有关。

Phlegm turbidness and obstruction is one of the main pathogenesis of coronary heart disease(CHD).Phlegm turbidness condenses,deposits blood vessels,obstructs qi and blood,and causes blood stasis.Phlegm and blood stasis are homologous,reciprocal,and jointly participate in the pathological process of CHD.Trichosanthes Peel Injection has been widely used in the treatment of CHD in clinic,which has the effect of reducing the symptoms of CHD and improving the clinical prognosis.However,its corresponding theoretical basis and scientific connotation need to be further improved and clarified.Therefore,under the guidance of the theory of Chinese medicine,in view of the etiology and pathogenesis of phlegm turbid arthralgia obstruction of CHD,this paper puts forward the therapeutic concept of Trichosanthes Peel Injection from phlegm and modulating phlegmstasis,and discusses its scientific connotation,with a view to providing a reference for the study of Trichosanthes Peel Injection in the prevention and treatment of CHD.