从《伤寒论》合病并病理论探讨脓毒症多脏器功能障碍

Discussion of MODS in Sepsis based on the Theory of Hebing and Bingbing in Treatise on Exogenous Febrile Disease

脓毒症具有高费用、高发病率、高死亡率的特征,在世界范围内已经成为死亡及危重疾病发生的重要因素之一,出现多脏器功能障碍是脓毒症的主要临床事件。尽管脓毒症在2016年才被新定义,人们对于脓毒症也有了更进一步的了解,但是我们对于脓毒症引起多脏器功能障碍的机制认识还不够全面。所以,进一步探索脓毒症多脏器功能障碍(MODS)的机制,是现今脓毒症多脏器功能障碍治疗的关键。本文以《伤寒论》合病并病理论为切入点,阐明了合病并病和脓毒症多脏器功能障碍之间的联系,从合病并病探讨中医对脓毒症多脏器功能障碍的治疗原则,以期为脓毒症多脏器功能障碍提供新思路和新途径,从而减少了临床病死率及致残率。

With the characteristics of high cost,high morbidity and high mortality,sepsis has become one of the major causes of death and critical illness worldwide.The occurrence of organ dysfunction is the most important clinical event of sepsis.Although the new definition of sepsis in 2016 has improved our understanding of sepsis,we still do not fully understand the mechanism of sepsis leading to organ dysfunction.Further exploration of the pathogenesis of multiple organ dysfunction syndrome(MODS)is the key to the treatment of sepsis with multiple organ dysfunction.Based on the theory of combined disease and disease in Treatise on Exogenous Febrile Disease,this paper expounds the relationship between Hebing and Bingbing and multiple organ dysfunction in sepsis,and explores the principle of traditional Chinese medicine in the treatment of MODS in sepsis,so as to provide new ideas and methods for the treatment of MODS in sepsis,and to reduce the clinical mortality and disability rate.