摘要
With the advantages of high sensitivity,rapid response,label-free,and simple operation,field effect transistor biosensors have shown promising application prospects in large-scale pathogen screening.However,in practical biological fluids with relatively high ionic strength,such as saliva and serum,the Debye screening effect will weaken the interaction between FET biosensors and target bio-molecules,thereby affecting the sensing sensitivity and accuracy.
基金
The National Key R&D Program of China(2017YFA0208000,2021YFA1202400)
the New Cornerstone Science Foundation through the XPLORER PRIZE are acknowledged for research funding
the Core Facility of Wuhan University for ATR-FTIR,SEM,and XPS analysis.The study was approved by the Ethics Committee of Renmin Hospital of Wuhan University(WDRY2022-K257)。
