摘要
中性粒细胞胞外诱捕网(neutrophil extracellular trap,NET)在17年前被发现,其在抗感染免疫中的作用不可估量。NET是由组蛋白和胞质颗粒蛋白组成的胞外DNA纤维,被认为是抵抗病原体入侵的天然免疫屏障,可以捕获病原体,降解细菌毒力因子并杀死细菌,对真菌、病毒和寄生虫均有一定的防御作用。此外,NET的过度形成可能导致一系列疾病,且携带的蛋白质也可损害组织。该文主要就NET在抗病原体感染、病原体对NET的免疫逃逸,以及NET的两面性作一综述。
Neutrophil extracellular trap(NET)discovered seventeen years ago has an essential role in anti-infection immunity.NETs are extracellular DNA fibers containing histones and cytoplasmic granular proteins.They were believed to form a natural immune barrier against pathogens invasion by trapping pathogens,degrading bacterial virulence factors,and killing bacteria.NETs also have effects against other pathogens including fungi,viruses,and parasites.However,the over-formation of NET can lead to a variety of diseases,and NET-associated proteins may also damage tissue.This review concentrates on the role of NET in defending pathogen infections,the immune escape of pathogens from NET,and the dual functions of NET.
作者
刘杰
贺樟平
吴移谋
LIU jie;HE Zhang-ping;WU Yi-mou(Institute of Pathogenic Biology Hengyang Medical School,University of South China,Hengyang 421001,China)
出处
《现代免疫学》
CAS
北大核心
2023年第5期439-443,共5页
Current Immunology
基金
国家自然科学基金面上项目(31872643)。
