MSC对T细胞的调节作用及其机制的研究进展

Research progress on the regulatory effect and mechanism of MSC on T cells

间充质干细胞(mesenchymal stromal cell,MSC)具有免疫抑制性,可通过调节各类免疫细胞反应,达到治疗炎症性疾病和自身免疫性疾病的目的。T细胞可识别多种病原体、肿瘤细胞,介导免疫反应并维持机体的免疫记忆和自我耐受。同时,T细胞也是多种炎症性和自身免疫性疾病的主要驱动因素。不同亚群T细胞在免疫反应中发挥不同的作用。其中,MSC通过表面分子以及分泌可溶性因子与T细胞建立直接或间接的联系,相互作用后产生抑制或促进效应。一方面,MSC介导抑制T细胞增殖的免疫效应,以达到免疫抑制作用。另一方面,MSC通过调节各类T细胞亚群分化纠正促炎因子(如IFN-γ、TNF-α)与抑炎因子(如IL-10)之间的失衡。文章就MSC调节各类T细胞亚群分化的机制展开综述。

Mesenchymal stromal cell(MSC)has immunosuppressive properties,and may inhibit inflammatory and autoimmune diseases by regulating various immune cell responses.T cells recognize a variety of pathogens and tumor cells,mediate immune responses,and maintain immune memory and self-tolerance.Meanwhile,T cells are also a major driver of various inflammatory and autoimmune diseases.Different subsets of T cells play different roles in the immune responses.MSC establishes direct or indirect contact with T cells through surface molecules and secretion of soluble factors and produces inhibitory or promotive effects after the interaction.On one hand,MSC mediates the inhibition of T cell proliferation to achieve immunosuppressive effects.On the other hand,MSC corrects the balance between pro-inflammatory factors(such as IFN-γand TNF-α)and anti-inflammatory factors(such as IL-10)by regulating the differentiation of various T cell subsets.This article reviews the mechanisms by which MSC regulates the differentiation of various T cell subsets.