运动激素鸢尾素在阿尔茨海默病中的作用机制

Mechanism of Action of the Exercise Hormone Irisin in Alzheimer's Disease

阿尔茨海默病(AD)是一种常见的神经退行性疾病,其主要特征为渐进性的认知功能和记忆能力衰退。众所周知,定期参与体育锻炼对大脑有积极影响,有助于预防与年龄相关的痴呆,并减缓AD的进展。然而,部分痴呆症患者由于年龄、身体限制等因素无法进行常规体育锻炼。因此,模拟运动效果的药物制剂就成了一种潜在的治疗选择。鸢尾素是一种与运动相关的激素,在调节能量代谢、炎症反应、突触可塑性等方面具有重要作用。本综述系统地回顾了鸢尾素在AD病理中的作用机制,并探讨其取代传统运动疗法的可能性。结果表明,鸢尾素通过诱导脑源性神经营养因子的表达来增强学习记忆,并通过调节免疫细胞的活化程度保护神经系统,同时改善胰岛素抵抗以减轻AD症状。综上,认为鸢尾素有望成为未来预防AD发病和改善AD病理的潜在靶点。

Alzheimer's disease is a common neurodegenerative disorder characterised by progressive decline in cognitive function and memory.Regular participation in physical activity is known to have a positive impact on the brain,help prevent age-related dementia and slow down the progression of Alzheimer's disease.However,some dementia patients are unable to engage in regular physical activity due to age and physical limitations.Therefore,pharmacological agents that mimic the effects of exercise become a potential therapeutic option.Irisin is an exercise-related hormone with important roles in the regulation of energy metabolism,inflammatory response,and synaptic plasticity.This review systematically reviews the mechanism of action of irisin in AD pathology and explores its potential to replace conventional exercise therapy.The results suggest that irisin enhances learning memory by inducing the production of brain-derived neurotrophic factor,protects the nervous system by modulating the activation of immune cells,and ameliorates insulin resistance to reduce AD symptoms.In conclusion,it believe that irisin is a potential target for preventing the onset of AD and ameliorating AD pathology in the future.