甲泼尼龙联合GnRH-α治疗子宫内膜异位症合并习惯性流产的效果观察

Observation on the Effect of Methylprednisolone Combined with GnRH-αin the Treatment of Endometriosis Complicated with Habitual Abortion

目的 探讨甲泼尼龙联合促性腺激素释放激素激动剂(GnRH-α)治疗子宫内膜异位症合并习惯性流产的效果。方法 选取本院在2020年1月-2023年1月时间段内接收的68例子宫内膜异位症合并习惯性流产患者作为研究对象,以随机数字表法作为分组依据,将其分成对照组(n=34)与观察组(n=34),对照组采用GnRH-α治疗,观察组在对照组基础上采用甲泼尼龙治疗,对比分析两组的炎症反应[C反应蛋白(CRP)、肿瘤坏死因子-α(TNF-α)、白介素-6(IL-6)]、性激素[促卵泡激素(FSH)、雌二醇(E2)、孕酮(P)]、治疗效果及不良反应发生率。结果 治疗后,两组CRP、TNF-α、IL-6水平均下降且观察组比对照组明显更低(P<0.05)。治疗后,两组FSH7水平均下降且观察组比对照组明显更低,E2、P水平均上升且观察组比对照组明显更高(P<0.05)。观察组治疗总有效率为94.12%,明显高于对照组的73.53%(P<0.05)。两组不良反应发生率对比无差异(P>0.05)。结论 甲泼尼龙联合GnRH-α治疗子宫内膜异位症合并习惯性流产效果确切,不仅有助于调节体内性激素水平,还能促进炎症消退,总体治疗效果显著,安全性可靠。

Objective To investigate the effect of methylprednisolone combined with gonadotropin-releasing hormone agonist(GnRH-α)in the treatment of endometriosis complicated with habitual abortion.Methos Sixty-eight cases of patients with endometriosis combined with habitual abortion received in our hospital from January 2020 to January 2023 were selected as research objects,and were divided into control group(n=34)and observation group(n=34)based on random number table method.The control group was treated with GnRH-α.The observation group was treated with methylprednisolone on the basis of the control group,and the inflammatory response[C-reactive protein(CRP),tumor necrosis factor-α(TNF-α),interleukin-6(IL-6)],sex hormone[follicle-stimulating hormone(FSH),estradiol(E2),progesterone(P)],therapeutic effect and incidence of adverse reactions of the two groups were compared.Results After treatment,the levels of CRP,TNF-αand IL-6 in both groups were decreased,and the levels in observation group were significantly lower than those in control group(P<0.05).After treatment,FSH levels of both groups decreased and the observation group was significantly lower than the control group,E2 and P levels increased and the observation group was significantly higher than the control group(P<0.05).The total effective rate of the observation group was 94.12%,which was significantly higher than that of the control group(73.53%)(P<0.05).There was no difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion Methylprednone combined with GnRH-αis effective in the treatment of endometriosis complicated with habitual abortion,which can not only help to regulate the level of sex hormones in the body,but also promote the regression of inflammation.The overall treatment effect is significant and safe.