基于无线自供能的植入式微纳集成芯片与集成系统

Wireless self-powered micro-nano integrated chip and integrated system for implantable medical devices

我国是慢性病大国,癌症、糖尿病、心脏病、癫痫、高血压等疾病已成为首要致死原因,医疗负担占比70%,形势严峻.相比口服,注射等传统给药方式,植入式精准靶向治疗按时按需、精准适量,见效迅速,几乎无副作用,被证实是慢性病的有效治疗方式.目前我国在这一领域刚刚起步,尤其在高端植入微纳集成系统级芯片(System of Chip,SoC)、微纳系统集成和封装可靠性等方面,缺少原创性核心技术和共性技术支撑平台,严重落后于欧美发达国家,相关高端医疗器械及核心部件只能高价进口.因此,需要通过突破相关关键共性技术,核心部件国产化,从创新源头推动高端医疗器械发展,从而加速推动我国医疗器械产业化落地,打破欧美日发达国家垄断.本研究以突破医疗用微纳集成芯片和微纳集成系统关键共性技术为目的,解决了微电子小尺寸、高精度、低功耗等难题.通过三维异质集成构建植入式精准靶向给药系统和迷走神经刺激器,实现精准靶向给药、无线充电、生物电信号采集、电刺激等功能,项目样机已通过生物相容性测试和动物实验验证.

Chronic diseases like cancer,diabetes,heart disease,epilepsy,and hypertension have become the leading causes of death in China,with 70%of the healthcare burden.Compared with traditional drug delivery methods such as oral administration and injection,implantable precision-targeted therapy has been proven to be an effective treatment for chronic diseases,with rapid results and virtually no side effects,as well as on-demand and precise dosage.At present,China is just in the beginning in this field,especially in high-end micro-nano integrated System on Chip(SoC)chips,micro-nano system integration and packaging reliability,etc.Original technology is not enough in China.Therefore,it is necessary to promote the development of high-end medical devices from the source of innovation by breaking through relevant key common technologies,localization of core components,to accelerate the industrialization of medical devices and break the monopoly of developed countries.This research aims to break through the key common technologies of micro-nano integrated chips and integrated systems for medical devices,and solves the problems of small size,high precision,and low power consumption of microelectronics.The implantable precision targeted drug delivery system and vagus nerve stimulator are constructed through three-dimensional heterogeneous integration,realizing the functions of precision targeted drug delivery,wireless charging,bioelectrical signal acquisition,and electrical stimulation,etc.The prototype of the project has been verified by biocompatibility tests and animal experiments.