益生菌治疗儿童功能性腹痛作用机制研究进展

Progress on the mechanism of probiotics in the treatment of funetional abdominal pain in ehildren

功能性腹痛(functional abdominal pain,FAP)是儿童常见的以腹痛为主要症状的疾病,严重影响着患儿的生活质量。儿童FAP的发病机制主要有脑-肠轴改变引起的胃肠道屏障功能受损、胃肠动力异常、内脏高敏感性、肠道菌群失调等多种因素。益生菌作为非药物治疗的重要手段对治疗儿童FAP有明显疗效。该文对益生菌治疗儿童FAP的作用机制进行阐述。

Functional abdominal pain(FAP)is a common disease with abdominal pain as the main symptom in children,which seriously affects the children's quality of life.FAP is caused mainly by changes in brain-gut axis,resulting in gastrointestinal barrier dysfunction,disturbed gastrointestinal motility,visceral hypersensitivity,intestinal dysbacteriosis and so on.Probiotics,as an important means of non-drug treatment,has obvious effect in the treatment of FAP.This article reviews the mechanism of probiotics in the treatment of FAP in children.