手术治疗主髂动脉疾病介入手术后感染6例临床分析

Clinical analysis of surgical treatment of infection after interventional operation for major iliac artery disease in 6 cases

目的:探讨主髂动脉相关疾病介入术后支架移植物感染的手术治疗策略。方法:回顾性分析2021年11月至2022年8月南京大学医学院附属鼓楼医院血管外科收治的6例主髂动脉相关疾病腔内治疗后继发支架移植物感染患者的临床资料。其中男性5例,女性1例,平均年龄64岁(范围:49~79岁)。距离支架移植物感染时间53~3165 d。6例患者均接受了手术治疗,其中3例采用人工血管施行了解剖外旁路移植术(腋动脉-股动脉、股动脉-股动脉),3例患者采用牛心包补片施行了腹主动脉原位重建术。记录患者围手术期情况、术后感染及严重不良事件的发生情况,评价不同治疗方式和材料的安全性。结果:所有患者顺利完成手术,住院治疗期间未发生死亡。术中出血量2000~5000 ml,术中输血量1600~5350 ml。术后随访81~395 d,所有患者手术切口愈合良好,无相关再感染事件发生。1例患者术后消化道出血,1例因术后血管吻合口处出血行二次手术(腹膜后血肿清除术),1例术后因下肢缺血先后进行双下肢截肢术,2例患者出现间歇性跛行。末次随访时所有患者均存活。结论:对于主动脉支架移植物感染患者,在感染可控且主动脉近远端有足够阻断空间时,主动脉原位重建是一种有效治疗方式,人工血管和牛心包补片均可取得较好短期效果。

Objective To explore the surgical treatment strategy of stent graft infection after interventional treatment of major iliac artery related diseases.Methods Retrospective analysis was performed on the clinical data of 6 patients with secondary stent graft infection after interventional treatment for major iliac artery related diseases admitted to the Department of Vascular Surgery,Affiliated Drum Tower Hospital,Medical School of Nanjing University from November 2021 to August 2022.There were 5 males and 1 female,with a mean age of 64 years(range:49 to 79 years).The infection time was 53 days to 3165 days.All the 6 patients received surgical treatment,including 3 patients who underwent anatomic bypass grafting(axillary arterial-femoral artery bypass,femoral arterial-femoral artery bypass)using artificial vessels,and 3 patients who underwent in situ abdominal aorta reconstruction using bovine pericardium.The perioperative situation,postoperative infection and the occurrence of serious adverse events were recorded,and the safety of different treatment methods and materials was evaluated.Results All patients successfully completed the operation and no death occurred during hospitalization.Intraoperative blood loss was 2000 to 5000 ml,and intraoperative blood transfusion was 1600 to 5350 ml.All the patients were followed up for 81 to 395 days after surgery,and the incision healed well,and no reinfection occurred.Postoperative gastrointestinal bleeding occurred in 1 patient,secondary surgery(retroperitoneal hematoma removal)was performed in 1 patient due to postoperative bleeding at the vascular anastomosis,both lower limb amputations were performed in 1 patient due to postoperative lower limb ischemia,and intermittent claudication occurred in 2 patients.All patients were alive at the last follow-up.Conclusion For patients with aortic stent graft infection,when the infection is not serious and there is enough space to block the proximal and distal aorta,in situ aortic reconstruction is an effective treatment,and different materials can achieve satisfactory results in a short period of time.