急性心肌梗死患者实施替格瑞洛配合急诊经皮冠状动脉介入的治疗效果探究

Objective to explore the effect of ticagrelor combined with emergency PCI in patients with acute myocardial infarction

目的 探讨替格瑞洛配合急诊经皮冠状动脉介入(percutaneous coronary intervention,PCI)治疗急性心肌梗死的临床价值。方法 选择2019年1月—2020年1月郧阳区中医医院收治的110例急性心肌梗死患者为研究对象,根据随机数字表法平均分为对照组与观察组,2组均行急诊PCI治疗,对照组给予氯吡格雷辅助治疗,观察组则运用替格瑞洛治疗,对比分析2组治疗效果。结果 2组患者治疗前的心功能对比差异无统计学意义(P>0.05);治疗后,与对照组相比,观察组的左室舒张末径(left ventricular end-diastolic dimension,LVEDD)水平下降,左室射血分数(left ventricular ejection fraction,LVEF)水平升高,差异有统计学意义(P<0.05);治疗后观察组的心肌梗死溶栓(thrombolysis in myocardial infarction,TIMI)、心肌灌注显影(TIMI Myocardial Blush Grades,TMPG)分级均优于对照组,差异有统计学意义(P<0.05)。观察组的心血管不良事件发生率低于对照组,差异有统计学意义(P<0.05)。结论 临床上在对急性心肌梗死患者进行急诊PCI治疗时辅助运用替格瑞洛,不仅可以改善心肌和血流灌注,还有助于恢复患者心功能,预防不良心血管事件发生,从而改善预后。

Objective To investigate the clinical value of ticagrelor combined with emergency percutaneous coronary intervention(PCI)in the treatment of acute myocardial infarction.Methods 110 patients with acute myocardial infarction admitted to Yunyang district hospital of traditional Chinese medicine from January 2019 to January 2020 were selected as the research objects,and they were divided into two groups according to the digital random method.The two groups were treated with emergency PCI,and the control group was given clopidogrel adjuvant treatment,while the observation group was treated with ticagrelor.Results There was no difference in cardiac function between the two groups before treatment(P>0.05).After treatment,compared with the control group,the level of LVEDD in the observation group decreased,and the level of LVEF increased,with a difference between the groups(P<0.05).After treatment,the TIMI and TMPG grades of the observation group were better than those of the control group,and there were differences between the groups(P<0.05).The incidence of adverse cardiovascular events in the observation group was lower than that in the control group,and the comparison between groups was statistically significant(P<0.05).Conclusion Clinical emergency PCI in patients with acute myocardial infarction,combined with ticagrelor,can not only improve myocardial and blood perfusion,but also help to restore cardiac function,and prevent adverse cardiovascular events,so as to improve the prognosis of patients.