中药治疗溃疡性结肠炎的代谢组学研究进展

Research progress on metabonomics of traditional Chinese medicine in the treatment of ulcerative colitis

溃疡性结肠炎(UC)作为临床消化系统的常见病、难治病,一直是医学研究的热点和难点。中医药在治疗UC方面具有疗效显著、安全性高、停药后不易反复等优势,但作用机制尚未完全阐明。代谢组学从整个机体内源性动态代谢角度出发,寻找潜在的生物标志物及代谢途径,有助于评价药物治疗效果和探索相关作用机制。中药治疗UC的代谢组学研究显示,中药复方、单味中药以及中药单体可通过调控机体内源性代谢物,作用于氨基酸代谢、脂质代谢、能量代谢等诸多相关通路,从而抑制免疫炎症反应、改善氧化应激、降低肠道敏感性、调节肠道菌群、修复肠道黏膜损伤,使机体恢复正常的代谢活动。但相关代谢标志物还需进一步筛选与验证。

OBJECTIVE Ulcerative colitis(UC),as a common and refractory disease of the digestive system,has always been a hot and difficult point in medical research.Traditional Chinese medicine has the advantages of good efficacy,high safety and not easy to relapse after drug withdrawal in the treatment of UC,but the mechanism has not been fully elucidated.Metabonomics looks for potential biomarkers and metabolic pathways from the point of view of the endogenous dynamic metabolism of the whole body,which is helpful to evaluate the efficacy of drugs and explore related mechanisms.Metabolomics studies on the treatment of UC with traditional Chinese medicine have shown that traditional Chinese medicine formulas,single herbs and herbs monomers act on various related pathways such as amino acid metabolism,lipid metabolism and energy metabolism by regulating endogenous metabolites in the body,thereby inhibiting immune inflammatory reactions,improving oxidative stress,reducing intestinal sensitivity,regulating intestinal microbiota,repairing intestinal mucosal damage,and restoring normal metabolic activity in the body.However,further screening and validation of relevant metabolic markers are needed.