磁共振T1 mapping技术评估肺动脉高压患者心肌组织特性的Meta分析

A Meta-analysis of myocardial tissue characteristics in patients with pulmonary hypertention evaluated by MR T1 mapping

目的通过Meta分析评估心脏磁共振定量T1 mapping技术对肺动脉高压(pulmonary hypertention,PH)患者心肌组织特性的诊断价值。材料与方法检索Pubmed、Web of Science、the Cochrane Library、中国知网、万方数据库、维普数据库自建库以来至2022年12月31日的相关文献,由2名研究人员根据纳入和排除标准独立筛选文献、提取资料并评价纳入文献质量后,采用Revman 5.4软件进行Meta分析。结果共纳入8篇文献,共计613例PH患者和150例健康对照。Meta分析结果显示,与健康对照相比,PH患者初始T1值显著增大[比值比(odds ratio,OR)=123.22,95%CI(112.92−133.52),P<0.001],在PH患者中下室间隔右心室插入部(inferior right ventricle insertion point,IRVIP)心肌初始T1值显著增大[OR=-82.94,95%CI(-92.43−-73.45),P<0.001]。结论磁共振T1 mapping技术可以无创评估PH患者心肌组织特性,具有较高的临床应用价值,需要密切关注IRVIP心肌。

Objective:To evaluate the diagnostic value of quantitative T1 mapping in cardiac magnetic resonance imaging for myocardial tissue characteristics in patients with pulmonary hypertention(PH)by Meta-analysis.Materials and Methods:Relevant literatures were retrieved from Pubmed,Web of Science,the Cochrane Library,CNKI,Wanfang Database and VIP Database from the establishment of the database to December 31,2022.Two researchers independently screened literatures,extracted data and evaluated the quality of the included literatures according to the inclusion and exclusion criteria.Meta-analysis was performed using Revman 5.4 software.Results:A total of 8 literatures were included,including 613 PH patients and 150 healthy controls.The results of Meta-analysis showed that compared with the healthy control group,the initial T1 value of PH patients was significantly increased[odds ratio(OR)=123.22,95%CI(112.92−133.52),P<0.001].Myocardial damage was obvious in inferior right ventricle insertion point(IRVIP)in PH group[OR=-82.94,95%CI(-92.43−-73.45),P<0.001].Conclusions:MR T1 mapping technique can evaluate the myocardial tissue characteristics of PH patients noninvasculatively,which has high clinical application value.Close attention should be paid to the myocardium of IRVIP.