磁共振成像技术在抑郁症经颅磁刺激治疗靶点选择中的应用进展

Advances in the application of magnetic resonance imaging in the localization of therapeutic targets for transcranial magnetic stimulation in depression

经颅磁刺激(transcranial magnetic stimulation,TMS)是临床治疗抑郁症的常用方法,然而其疗效不一,这可能与刺激靶点的定位不同有关。近年来,随着磁共振成像(magnetic resonance imaging,MRI)技术的发展,利用MRI结构和功能像数据寻找TMS抗抑郁靶点成为当前的研究热点。因此,本文综述了MRI在TMS抗抑郁靶点选择中的应用进展,包括以下几个方面:利用MRI结构像可以进行更为精准的脑区划分及毫米级靶点坐标的定义;通过MRI功能像计算功能连接和有效连接等参数来确定个体化刺激靶点的位置;结合MRI结构像的辅助定位法帮助操作者准确定位到目标刺激靶点。本综述旨在整理相关研究,为提高TMS临疗效提供相关参考。

Transcranial magnetic stimulation(TMS)is widely used in clinical interventions for depression,but its efficacy varies,possibly due to differences in target site localization.In recent years,with the development of magnetic resonance imaging(MRI)technology,the use of MRI structural and functional data to identify TMS targets for antidepressant effects has become a research hotspot.Therefore,this review summarized the application progress of MRI in TMS target site selection for depression treatment,including the following aspects:Precise brain region delineation and definition of millimeter-level target coordinates using MRI structural imaging;Determination of individualized stimulation target locations by calculating functional connectivity and effective connectivity parameters from MRI functional imaging;The use of MRI structural imaging for assisted targeting to help operators accurately locate the target stimulation sites.This review aims to compile relevant research and provide references for improving the clinical efficacy of TMS.