桑菊清解汤联合穴位敷贴对慢性阻塞性肺疾病急性加重期痰热蕴肺证患者中医证候的影响

Effect of Sangju Qingjie decoction combined with acupoint application on traditional Chinese medicine syndrome of patients with acute exacerbation of chronic obstructive pulmonary disease complicated by phlegm-heat accumulated in lung

目的分析桑菊清解汤联合穴位敷贴对慢性阻塞性肺疾病急性加重期(AECOPD)痰热蕴肺证患者的治疗效果。方法抽取2022年2月至2023年2月新密市中医院收治的AECOPD痰热蕴肺证患者96例,按随机数字表法分为对照组和观察组,每组48例。对照组给予常规西医+穴位贴敷治疗,观察组加用桑菊清解汤治疗,连续治疗2周。比较两组临床疗效,比较两组治疗前后中医证候评分、炎症因子[C反应蛋白(CRP)、白细胞介素-6(IL-6)]水平及肺功能[第1秒用力呼气容积(FEV1)、用力肺活量(FVC)、呼气峰值流速(PEF)],比较两组不良反应发生率。结果观察组治疗总有效率(93.75%,45/48)高于对照组(79.17%,38/48),P<0.05。治疗前,两组喘息、咳嗽、咳痰黏稠度评分及CRP、IL-6、FEV1、FVC、PEF水平比较,差异未见统计学意义(P>0.05);治疗后,观察组喘息、咳嗽、咳痰黏稠度评分均低于对照组(P均<0.05),CRP、IL-6水平低于对照组(P<0.05);治疗后,观察组FEV1、FVC、PEF高于对照组(P<0.05)。两组不良反应发生率比较差异未见统计学意义(P>0.05)。结论桑菊清解汤联合穴位敷贴能够减轻AECOPD痰热蕴肺证患者症状,减轻炎症反应,改善肺功能,且不会引起严重不良反应.

Objective To analyze the therapeutic effect of Sangju Qingjie decoction combined with acupoint application on patients with acute exacerbation of chronic obstructive pulmonary disease(AECOPD)complicated by phlegm-heat accumulated in lung.Methods Ninety-six AECOPD patients with syndrome of phlegm-heat accumulated in lung admitted to Xinmi Hospital of Traditional Chinese Medicine from February 2022 to February 2023 were selected,and they were divided into control group and observation group according to random number table method,with 48 cases in each group.The control group was treated with routine western medicine and acupoint application,while the observation group was treated with Sangju Qingjie decoctiom based on the treatment of the control group;both groups were treated for 2 consecutive weeks.The clinical efficacy of the two groups were compared;the traditional Chinese medicine syndrome scores,levels of inflammatory factors,including C-reactive protein(CRP)and interleukin-6(IL-6),lung function assessed by forced expiratory volume in 1 second(FEV1),forced vital capacity(FVC)and peak expiratory flow(PEF)of the two groups were compared before and after treatment.The incidence of adverse reactions in the two groups were compared.Results The total effective rate of the observation group was 93.75%(45/48),higher than the 79.17%(38/48)of the control group(P<0.05).Before treatment,there was no significant difference between the two groups in the scores of syndrome(wheezing,coughing and sputum viscosity)and the levels of CRP,IL-6,FEV1,FVC and PEF(P>0.05);after treatment,the observation group had lower scores of wheezing,coughing,and sputum viscosity(all P<0.05),and lower levels of CRP and IL-6,compared with the control group(P<0.05).After treatment,the FEV1,FVC,and PEF in the observation group were higher than those in the control group(P<0.05).There was no statistically significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusions Sangju Qingjie decoction combined with acupoint application can alleviate the symptoms of AECOPD patients with phlegm-heat accumulated in lung,reduce inflammatory reactions,improve lung function,and not cause serious adverse reactions.