摘要
帕金森病(PD)是一种常见的神经退行性疾病,其发病率随年龄增长而增高。α-突触核蛋白的错误折叠和异常聚集是帕金森病关键的神经病理标志。近期研究显示,外泌体也可能通过其运输与转载功能推动病理性α-突触核蛋白在大脑中传播,进一步促进帕金森病的发展,从而参与帕金森病的致病机制。外泌体是一种纳米级囊泡,其直径较小的优势在帕金森病治疗中有望发挥较大作用。本文综述了外泌体在帕金森病发生中的作用和具有潜在临床应用价值的研究进展。
Parkinson's disease(PD)is a common neurodegenerative disease,and its incidence increases with age.The incorrect folding and abnormal aggregation ofα-synuclein are the key neuropathological markers of PD.Recent studies have shown that exosomes may also promote the pathologicalα-synuclein spreads in brain through their transport and transfer functions,further promoting the development of PD,thus participating in the pathogenesis of PD.Exosomes are nanoscale extracellular vesicles,the advantage of its smaller diameter is expected to play a significant role in treatment of PD.This article reviews the related research progress on the role of exosome and its potential clinical application in PD.
作者
范丽珊
樊慧杰
李艳荣
肖琪
贾璐
秦劭晨
王利然
肖保国
马存根
柴智
Fan Li-Shan;Fan Hui-Jie;Li Yan-Rong;Xiao Qi;Jia Lu;Qin Shao-Chen;Wang Li-Ran;Xiao Bao-Guo;Ma Cun-Gen;Chai Zhi(The Key Research Laboratory of Benefiting Qi for Acting Blood Circulation Method to Treat Multiple Sclerosis of State Administration of Traditional Chinese Medicine/Neurobiology Research Center,Shanxi University of Chinese Medicine,Jinzhong,Shanxi 030619,China;The First Clinical College of Shanxi University of Traditional Chinese Medicine,Taiyuan,Shanxi 030024,China;The Second Clinical College of Shanxi University of Traditional Chinese Medicine,Taiyuan,Shanxi 030012,China;Institute of Neurology,Huashan Hospital,Institutes of Brain Science and State Key Laboratory of Medical Neurobiology,Fudan University,Shanghai 200025,China)
出处
《解放军医学杂志》
CAS
CSCD
北大核心
2023年第10期1214-1220,共7页
Medical Journal of Chinese People's Liberation Army
基金
山西省青年拔尖人才支持计划项目(2019年)
山西省省筹资金资助回国留学人员科研项目(2021-142)
山西省“四个一批”科技兴医创新计划医学科技领军人才项目(2020RC05)
山西省晋中市科技重点研发计划(社会发展)项目(Y213004)。
