间充质干细胞对细胞焦亡的调控作用及机制研究进展

Research progress on the regulatory role and mechanism of mesenchymal stem cells in pyroptosis

细胞焦亡是一种胱天蛋白酶(caspase)依赖的、Gasdermin蛋白介导的炎症性程序性细胞死亡方式,参与多种疾病的发生和发展。间充质干细胞(MSCs)是来源于中胚层的一类成体多能干细胞,广泛分布于人体多种组织中,具有较强的分泌能力,可以通过分泌外泌体、微泡、细胞因子等物质调节小胶质细胞表型的转变、促进线粒体自噬、保护线粒体的功能、调控内质网应激及钙稳态,从而抑制炎性小体介导的细胞焦亡,延缓疾病进展及改善预后。此外,有文献报道MSCs本身也可发生焦亡。本文对MSCs对细胞焦亡的调控作用及机制研究进展进行综述,以加深人们对MSCs与细胞焦亡关系的了解。

Pyroptosis is a caspase-dependent,gasdermin protein mediated inflammatory programmed cell death mode,which is involved in the occurrence and development of a variety of diseases.Mesenchymal stem cells(MSCs)are adult pluripotent stem cells derived from the mesoderm and widely distributed in various tissues of human body and show strong secretory capacity.Exosomes,microvesicles,cytokines and other substances secreted by MSCs can regulate microglia phenotypic transformation,promote mitochondrial autophagy,protect mitochondrial function,regulate endoplasmic reticulum stress and calcium homeostasis,thereby inhibiting the pyroptosis mediated by inflammasome and improving the progression and prognosis of related diseases.In addition,pyroptosis has also been reported in MSCs itself.In present paper,the research progress has been reviewed on the role and mechanism of MSCs in regulating pyroptosis,so as to deepen people's understanding on the relationship between MSCs and cell pyroptosis.