阴道微生态对人乳头瘤病毒感染的影响

Effect of vaginal microecology on human papilloma virus infection

目的分析阴道微生态对人乳头瘤病毒(HPV)感染的影响。方法选取2020年5月至2022年12月在扬州市妇幼保健院治疗的80例HPV感染患者为HPV组,另选取同期健康体检的80例女性为参考组。比较两组阴道微生态情况,包括外阴阴道假丝酵母菌病(VVC)、滴虫性阴道炎(TV)及细菌性阴道病(BV)等,并采用多因素logistic回归分析HPV感染的影响因素。结果两组清洁度、菌群密集度、菌群多样性、pH值、过氧化氢含量及VVC、TV、BV比较,差异有统计学意义(P<0.05);多因素logistic回归分析显示,清洁度、菌群密集度、菌群多样性异常及pH值>4.5、过氧化氢含量<2μmol/L、VVC、TV、BV是HPV感染的影响因素(P<0.05)。结论阴道微生态异常会增加HPV感染的风险。

Objective To analyze the effect of vaginal microecology on human papilloma virus(HPV)infection.Methods A total of 80 patients with HPV infection treated in Yangzhou Maternal and Child Health Hospital from May 2020 to December 2022 were selected as the HPV group,and 80 women who underwent physical examination during the same period were selected as the reference group.The vaginal microecology,including vulvovaginal candidiasis(VVC),trichomonas vaginitis(TV)and bacterial vaginosis(BV),was compared between the two groups,and the influencing factors of HPV infection were analyzed by multivariate logistic regression.Results There were statistically significant differences in cleanliness,flora density,flora diversity,pH value,hydrogen peroxide content,VVC,TV,and BV between the two groups(P<0.05).Multivariate logistic regression analysis showed that cleanliness,flora density,abnormal flora diversity,pH value>4.5,hydrogen peroxide content<2μmol/L,VVC,TV and BV were the influencing factors of HPV infection(P<0.05).Conclusion Abnormal vaginal microecology can increase the risk of HPV infection.