摘要
动脉粥样硬化(atherosclerosis,AS)的发病机理复杂,是诸多心血管疾病的病理基础。自噬是一种细胞自身的分解代谢机制,细胞自噬功能障碍与许多疾病的发生和发展密切相关。天然产物是自然界中动植物所含化学成分的统称,越来越多的研究揭示了天然产物在治疗人类疾病中的巨大潜力,本文就近年来天然产物基于细胞自噬改善AS的研究进行综述。
The pathogenesis of atherosclerosis(AS)is complex and is the pathological basis of various cardiovascular diseases.Autophagy is a catabolic mechanism of cells,and the dysfunction of autophagy is closely related to the occurrence and development of many human diseases.A growing body of research has revealed the potential of natural products,the collective name for the chemical components found in nature,to treat human diseases.Here,the recent studies on the improvement of AS by natural products based on autophagy are reviewed.
作者
杨晋勃
蒙温露儿
胡丹丹
黄业伟
YANG Jin-bo;MENG Wen-lu-er;HU Dan-dan;HUANG Ye-wei(Key Laboratory of Pu′er Tea Science of Ministry of Education,Yunnan Agricultural University;College of Food Science and Technology,Yunnan Agricultural University;College of Science,Yunnan Agricultural University,Kunming 650201,China)
出处
《天然产物研究与开发》
CAS
CSCD
2023年第11期1991-2002,共12页
Natural Product Research and Development
基金
云南省“兴滇英才支持计划”(YNWR-QNBJ-2018-083)
云南省科技人才和平台计划(2019HB021)。
关键词
动脉粥样硬化
自噬
天然产物
atherosclerosis
autophagy
natural product
