BiPAP无创呼吸机治疗慢性阻塞性肺疾病急性加重合并呼吸衰竭患者的效果

Effects of BiPAP noninvasive ventilator in treatment of patients with acute exacerbation of COPD complicated with respiratory failure

目的:观察双水平气道正压通气(BiPAP)无创呼吸机治疗慢性阻塞性肺疾病急性加重(AECOPD)合并呼吸衰竭患者的效果。方法:选取2020年1月至2021年5月该院收治的80例AECOPD合并呼吸衰竭患者进行前瞻性研究,按照随机数字表法分为对照组和观察组各40例。对照组在常规治疗基础上予以低流量吸氧,观察组在对照组基础上采用BiPAP无创呼吸机治疗。比较两组临床疗效、住院时间、治疗前后肺功能指标[最大呼气流量(PEF)、用力肺活量(FVC)、第1秒用力呼气容积(FEV1)占FVC的百分比(FEV1/FVC)]水平、心率、呼吸频率和生命质量[简明健康状况调查问卷(SF-36)]评分。结果:观察组治疗总有效率为95.00%,明显高于对照组的80.00%,差异有统计学意义(P<0.05);治疗后,两组PEF、FVC、FEV1/FVC水平均高于治疗前,且观察组高于对照组,差异有统计学意义(P<0.05);治疗后,两组心率和呼吸频率均低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05);观察组住院时间为(13.12±2.15)d,短于对照组的(17.82±2.96)d,差异有统计学意义(t=0125,P=0.000);治疗后,两组各项生命质量评分均高于治疗前,且观察组高于对照组,差异有统计学意义(P<0.05)。结论:BiPAP无创呼吸机治疗AECOPD合并呼吸衰竭患者可提高治疗总有效率、肺功能指标水平和生命质量评分,缩短住院时间,降低心率和呼吸频率,效果优于低流量吸氧。

Objective:To observe effects of bilevel positive airway pressure(BiPAP)in treatment of patients with acute exacerbation of chronic obstructive pulmonary disease(AECOPD)complicated with respiratory failure.Methods:A prospective study was conducted on the clinical data of 80 patients with AECOPD complicated with respiratory failure admitted to this hospital from January 2020 to May 2021.They were divided into control group and observation group according to the random number table method,40 cases in each.The control group was treated with low flow oxygen,while the observation group was treated with BiPAP noninvasive ventilator on the basis of that of the control group.The clinical treatment effect,the hospitalization time,the lung function index levels[maximum expiratory flow(PEF),forced vital capacity(FVC),percentage of forced expiratory volume in one second(FEV1)to FVC(FEV1/FVC)],the heart rate,the respiratory rate,and the quality of life[short form health survey(SF-36)]score were compared between the two groups before and after the treatment.Results:The total effective rate of the observation group was 95.00%,which was significantly higher than 80.00%of the control group,and the difference was statistically significant(P<0.05).After the treatment,the levels of PEF,FVC and FEV1/FVC in the two groups were higher than those before the treatment,those in the observation group were higher than those in the control group,and the differences were statistically significant(P<0.05).After the treatment,the heart rate and the respiratory rate of the two groups were lower than those before the treatment,those in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).The hospitalization time of the observation group was(13.12±2.15)d,which was shorter than the control group of(17.82±2.96)d,and the difference was statistically significant(t=0125,P=0.000).Further,after the treatment,the quality of life scores of the two groups were higher than those before the treatment,that in the observation group was higher than that in the control group,and the differences were statistically significant(P<0.05).Conclusions:On the basis of the conventional treatment,the BiPAP noninvasive ventilator can improve the total effective rate,the lung function index levels and the quality of life scores,shorten the hospitalization time,and reduce the heart rate and the respiratory rate in the patients with AECOPD complicated with respiratory failure.Moreover,it is superior to single low flow oxygen.