肺部理疗联合盐酸氨溴索雾化吸入对肺炎患儿血气指标及康复的影响

Effect of lung physiotherapy combined with aerosol inhalation of ambroxol hydrochloride on blood gas index and rehabilitation of children with pneumonia

目的探讨肺部理疗联合盐酸氨溴索雾化吸入治疗肺炎患儿的效果。方法选取2019年8月至2020年8月本院收治的264例肺炎患儿作为研究对象,按照随机数字表法分为两组,各132例。对照组给予盐酸氨溴索化吸入治疗,观察组在对照组基础上联合肺部理疗,比较两组临床疗效、动脉血气分析指标、肺功能、康复效果、不良反应发生率。结果观察组治疗总有效率高于对照组,差异有统计学意义(P<0.05)。治疗前,两组氧气分压(PaO_(2))、二氧化碳分压(PaCO_(2))比较差异无统计学意义;治疗7 d后,两组PaO_(2)均高于治疗前,PaCO_(2)均低于治疗前,且观察组PaO_(2)高于对照组,PaCO_(2)低于对照组,差异有统计学意义(P<0.05)。治疗前,两组呼气流量峰值(PEF)、第1秒用力呼气容积(FEV_(1))、用力肺活量(FVC)比较差异无统计学意义;治疗7 d后,两组PEF、FEV_(1)、FVC均高于治疗前,且观察组高于对照组,差异有统计学意义(P<0.05)。观察组咳嗽、气促、肺啰音消失时间均短于对照组,差异有统计学意义(P<0.05)。两组不良反应发生率比较差异无统计学意义。结论肺部理疗联合盐酸氨溴索雾化吸入可有效改善患儿动脉血气分析指标,有利于促进肺功能恢复及症状缓解,且无严重不良反应,安全性较高。

Objective To explore the effect of lung physiotherapy combined with aerosol inhalation of ambroxol hydrochloride on children with pneumonia.Methods 264 children with pneumonia admitted to our hospital from August 2019 to August 2020 were selected as the study subjects,and they were divided into two groups according to the random number table method,with 132 cases in each group.The control group was given ambroxol hydrochloride inhalation treatment,and the observation group was combined with lung physiotherapy on the basis of the control group,the clinical efficacy,arterial blood gas analysis index,lung function,rehabilitation effect and adverse reactions were compared between the two groups.Results The total effective rate in the observation group was higher than that in the control group,and the difference was statistically significant(P<0.05).Before treatment,there was no statistically significant difference in partial pressure of oxygen(PaO_(2)),partial pressure of carbon dioxide(Pa-CO_(2))between the two groups;after 7 d of treatment,PaO_(2) of the two groups was higher than that before treatment,and PaCO_(2) was lower than that before treatment,and PaO_(2) in the observation group was higher than that in the control group,and PaCO_(2) was lower than that in the control group,the differences were statistically significant(P<0.05).Before treatment,there was no significant difference in peak expiratory flow(PEF),forced expiratory volume in the one second(FEV_(1)),and forced vital capacity(FVC)between the two groups;after 7 d of treatment,PEF,FEV_(1) and FVC of the two groups were higher than before treatment,and the observation group was higher than the control group,the differences were statistically significant(P<0.05).The disappearance time of cough,shortness of breath,and lung rales in the observation group were shorter than those in the control group,and the differences were statistically significant(P<0.05).There was no statistically significant difference in the incidence of adverse reactions between the two groups.Conclusion Lung physiotherapy combined with aerosol inhalation of ambroxol hydrochloride can effectively improve the arterial blood gas analysis indexs of children,which is conducive to promoting the recovery of lung function and symptom relief,without serious adverse reactions,and have high safety.