良性与恶性血液病经造血干细胞移植后患儿生存质量的对比及其影响因素分析

Comparison of quality of life and analysis of influencing factors in children with benign and malignant diseases after hematopoietic stem cell transplantation

目的探究造血干细胞移植患儿术后生存质量及其影响因素。方法采用PedsQL^(TM)3.0儿童生存质量移植模块量表中文版对2016年1月—2020年10月期间在徐州医科大学附属医院接受造血干细胞移植的60例患儿的生存质量进行调查,比较良性病与恶性病病人造血干细胞移植后的生存质量,并且分析其影响因素。结果PedsQL^(TM)3.0儿童生存质量移植模块量表中文版家长量表良性病生存质量各维度及总表的得分均高于80分,且除疼痛与伤害外,其余各维度及总表的生存质量得分均高于恶性病(P<0.05)。PedsQL^(TM)3.0儿童生存质量移植模块量表中文版儿童自评量表良性病生存质量各维度及总表的得分均高于80分,且均高于恶性病(P<0.05)。cGVHD对移植组患儿生存质量有著影响(P<0.05),性别、年龄、供者来源、父亲文化程度、母亲文化程度与移植组患儿生存质量无相关性(P>0.05)。结论造血干细胞移植后良性病病人的生存质量整体高于恶性病病人,cGVHD是影响移植后患儿生存质量的重要因素。

Objective To Investigate the quality of life(QOL)after hematopoietic stem cell transplantation(HSCT)and its influencing factors in children.Methods The QOL of 60 children who successfully received HSCT in the Affiliated Hospital of Xuzhou Medical University from January 2016 to October 2020 was investigated by PedsQL^(TM)3.0 Children′s Quality of Life Transplant Module Scale Chinese Edition.The QOL after HSCT in patients with benign and malignant diseases was compared,and the influencing factors affecting the QOL after HSCT were analyzed.Results For Benign Disease,the Parent Scale Quality of Survival Score of PedsQL^(TM)3.0 Children′s Quality of Life Transplant Module Scale Chinese Version in each dimension and the total table are higher than 80 points,and except for pain and injury,the survival quality scores of the remaining dimensions and the total table in benign diseases were higher than that in malignant diseases(P<0.05).For Benign Disease,the Children′s Self-Assessment Scale Quality of Survival Score of PedsQL^(TM)3.0 Children′s Quality of Life Transplant Module Scale Chinese Version in each dimension and the total table are higher than 80 points,and the survival quality scores of all dimensions and the total table in benign diseases were higher than that in malignant diseases(P<0.05).Chronic graft-versus-host-disease(cGVHD)had an effect on the QOL of children received HSCT(P<0.05).Sex,age,donor source,paternity and maternal literacy were not correlated with the QOL of the children received HSCT(P>0.05).Conclusions The overall QOL of benign patients after HSCT is higher than that of patients with malignant diseases,and cGVHD is an important factor affecting the QOL after HSCT.