肠道菌群相关代谢产物影响骨代谢的研究进展

Intestinal flora affecting metabolites and bone metabolism:research progress

肠道菌群是包括细菌和真菌在内的多种微生物的总称,定植于宿主肠道中,与宿主形成复杂的共生关系,在维持人体健康中起重要作用。目前肠道菌群调节骨代谢已经成为研究的热点,除了肠道菌群影响骨代谢外,肠道菌群的代谢产物也可以影响骨代谢。肠道菌群代谢产物,如短链脂肪酸、色氨酸、胆汁酸、硫化氢和维生素B等都对骨代谢有直接或间接的影响。本文对肠道菌群相关代谢产物影响骨代谢的机制进行探讨,以期为治疗骨质疏松症提供新的思路。

Intestinal flora is a general term for a variety of microbial communities,including bacteria,fungi and viruses,which colonize the host's intestinal tract and form a complex symbiotic relationship with the host,playing an important role in maintaining human health.In recent years,the regulation of bone metabolism by intestinal flora has become a hot research topic.In addition to the influence of intestinal flora on bone metabolism,the metabolites of intestinal flora can also affect bone metabolism.The metabolites of intestinal flora,such as short-chain fatty acid,tryptophan,bile acid,hydrogen sulfide and vitamin B,have direct or indirect effects on bone metabolism.In this paper,the mechanism of intestinal microbiota metabolites affecting bone metabolism was discussed to provide new ideas for the treatment of osteoporosis.