帕金森病患者骨质疏松性骨折的发病机制研究进展

Recent advance in pathogenesis of osteoporotic fracture in patients with Parkinson's disease

近年来大量研究发现帕金森病(PD)患者常并发骨质疏松性骨折,这可能与PD相关的多巴胺递质减少、PD风险基因突变、线粒体功能障碍、维生素D减少、抗PD药物的使用、自主神经功能障碍以及肠道菌群失调等有关。本文针对当前PD患者骨质疏松性骨折的发病机制研究进展进行综述,以期为PD和骨质疏松性骨折的共病治疗提供基础理论依据。

In recent years,a large number of studies have found that Parkinson's disease(PD)patients often complicate with osteoporotic fracture,which may be related to decreased dopamine transmitters,PD risk gene mutations,mitochondrial dysfunction,vitamin D reduction,anti-PD drug use,autonomic nervous dysfunction and intestinal microflora disorders.Therefore,this paper reviews the current research progress on the pathogenesis of osteoporotic fracture in PD patients to provide theoretical basis for co-morbid treatment of PD and osteoporotic fracture.