基于缺氧诱导因子探讨高原抑郁症发病机制的研究进展

Recent advance in pathogenesis of high altitude depression based on hypoxia-inducible factors

抑郁症是严重威胁生命健康的精神疾病,发病机制错综复杂。近期研究发现海拔高度是导致抑郁症发病的重要因素之一。缺氧诱导因子为低氧条件下的重要转录因子,其中缺氧诱导因子-1参与急性低氧调控,介导神经营养因子和5-羟色胺等上调,促进大脑代谢,对抗抑郁;缺氧诱导因子-2参与慢性低氧调控,促进炎症反应,加重抑郁。本文重点介绍缺氧诱导因子与高原抑郁症发病的相关研究,旨在为深入探究高原抑郁症的发病机制及防治提供新思考。

Depression is a mental disease that seriously threatens life and health,and its pathogenesis is complicated.Recent studies have found that altitude is one of the important factors leading to depression.As an important transcription factor under hypoxic condition,hypoxia-inducible factor-1 regulates acute hypoxia,and upregulates neurotrophic factor and 5-hydroxytryptamine,thus exerting antidepressant effect by promoting brain metabolism;hypoxia-inducible factor-2 regulates chronic hypoxia,promotes inflammation and aggravates depression.This article focuses on the related research on hypoxia-inducible factors and pathogenesis of high altitude depression,to further explore the pathogenesis and prevent high altitude depression.