调神益智汤联合哌甲酯及脑电生物反馈治疗学龄期儿童注意力缺陷多动障碍临床观察

Clinical Observation of Tiaoshen Yizhi Decoction Combined with Methylphenidate and Electroencephalogram Biofeedback in the Treatment of Attention Deficit Hyperactivity Disorder in School-Age Children

目的 探讨调神益智汤联合哌甲酯及脑电生物反馈治疗学龄期儿童注意力缺陷多动障碍(ADHD)的效果。方法 选取医院2022年5月至2023年3月收治的学龄期ADHD患儿102例,按治疗方案的不同分为对照组(43例)和观察组(59例)。两组患儿均予盐酸哌甲酯片口服联合脑电生物反馈治疗,观察组患儿加用调神益智汤内服。两组患儿均持续治疗12周。结果 观察组总有效率为88.14%,显著高于对照组的69.77%(P <0.05)。治疗后,两组患儿的中医证候积分、中文版Conners父母用症状问卷(PSQ)评分均显著降低,中国修订韦氏儿童智力量表(C-WISC)评分、前额叶血氧合血红蛋白相对水平均显著升高,且观察组变化幅度均显著大于对照组(P <0.05)。观察组不良反应发生率与对照组相当(8.47%比18.60%,P> 0.05)。结论 调神益智汤联合哌甲酯及脑电生物反馈治疗学龄期ADHD,可进一步改善患儿的中医证候和脑功能指标,更有效缓解临床病症。

Objective To investigate the efficacy of Tiaoshen Yizhi Decoction combined with methylphenidate and electroencephalogram(EEG)biofeedback in the treatment of attention deficit hyperactivity disorder(ADHD)in school-age children.Methods A total of 102 school-age children with ADHD admitted to the hospital from May 2022 to March 2023 were selected and divided into the control group(43 cases)and the observation group(59 cases)according to different treatment plans.Both groups were treated with Methylphenidate Hydrochloride Tablets(orally)combined with EEG biofeedback,on this basis,the children in the observation group were treated with Tiaoshen Yizhi Decoction orally.Both groups were treated continuously for 12 weeks.Results The total effective rate in the observation group was 88.14%,which was significantly higher than 69.77%in the control group(P<0.05).After treatment,the traditional Chinese medicine(TCM)syndrome score and the Conners Parent Symptom Questionnaire(PSQ,Chinese version)score in the two groups were significantly lower,the Chinese Wechsler Intelligence Scale for Children(C-WISC)score and relative level of prefrontal oxyhemoglobin were significantly higher,and the above indexes in the observation group changed more significantly than those in the control group(P<0.05).The incidence of adverse reactions in the observation group was similar to that in the control group(8.47%vs.18.60%,P>0.05).Conclusion Tiaoshen Yizhi Decoction combined with methylphenidate and EEG biofeedback in the treatment of ADHD can further improve the TCM syndromes and brain function indexes of school-age children,and alleviate effectively clinical symptoms.