丁酸盐在多发性硬化中的积极作用及其机制研究

Positive effect and mechanism of butyrate in multiple sclerosis

多发性硬化(MS)是一种慢性免疫介导的中枢神经系统(CNS)疾病,近年来肠道微生物群及其发酵代谢产物,如短链脂肪酸(SCFAs),与MS病程进展的关系受到高度关注。本综述回顾短链脂肪酸如何直接或间接参与免疫调节,进而指出丁酸盐在脱髓鞘和再髓鞘中的积极作用,得出丁酸盐调节MS的机制。揭示了肠道微生物群代谢产物与CNS相互作用的密切关联,并可能为控制MS的脱髓鞘和再髓鞘化提供新策略。

Multiple sclerosis(MS)is a chronic immune-mediated disease of the central nervous system(CNS).In recent years,relationship between gut microbiome and its fermentation metabolites,such as short-chain fatty acids(SCFAs),and development and course of MS has received increasing attention.This review explores how short-chain fatty acids are directly or indirectly involved in immune regulation,and further studies the positive role of butyrate in demyelination and remyelination,and summarizes the mechanism by which butyrate regulates MS.These findings reveal the close relationship between gut microbiome metabolites and interaction of CNS,and may provide a new strategy for the control of demyelination and remyelination in MS.