基于B7-H3靶点的分子影像技术在肿瘤诊断方面的研究进展

Advances in molecular imaging of B7-H3-targeted in context of tumor diagnostic

寻找新的治疗靶点用于准确的癌症早期诊断是目前肿瘤精准治疗亟待解决的问题之一。B7-H3(CD276)曾被称为“肿瘤相关抗原”,在肿瘤组织中广泛异常高表达,在正常组织上表达受限,使其成为各种靶向肿瘤的造影剂及肿瘤治疗的理想分子。分子影像通过分子影像探针以非侵入性形式显示肿瘤病理生理特征,可用于诊断、治疗及各种靶向治疗(包括免疫治疗)的效果评估。因此,本文主要综述以B7-H3为靶点的分子影像在肿瘤诊断中的最新研究进展。

Looking for a cancer therapeutic targeted used in diagnosis is in the spotlight as one solution in the precise fight against cancer.B7-H3(CD276)was once known as a"tumor-associated antigen",which is aberrantly expressed in a high proportion of human malignancies but limited expression in normal human tissues,making it an ideal target for various contrast agents and cancer treatment.Molecular imaging with molecular imaging probes,noninvasively,demonstrate pathophysiologic features of cancer for diagnostic,treatment,and response assessment considerations for various targeted therapies,including immunotherapy.Herein,we review the latest developments in molecular imaging of B7-H3 targeted in the context of cancer diagnostic.