A-D-A covalent organic-inorganic heterojunctions with enhanced photocatalytic performance for robust anti-bacteria

Background:Organic semiconductors have attracted much attention due to their excellent biocompatibility,tunable electronic structure,low cost,and antimicrobial phototherapy.However,owing to the high exciton binding energies,organic semiconductor is constrained by their short exciton diffusion length,leading to inefficient transportation of photogenerated carriers and deficient antibacterial capability.Methods:To address this issue,a quad-channel synergistic antibacterial nano-platform of copper sulfide/organic semiconductor(CuS/IEICO-4F)heterojunctions with enhanced photocatalytic performance is designed and manufactured,which can produce localized heat and raise the levels of extracellular reactive oxygen species under near-infrared laser irradiation.Simultaneously,the released Cu2+can consume intrabacterial glutathione,destroying the defense system and ultimately leading to bacterial inactivation.Results:In vitro antibacterial experiments demonstrate that the organic-inorganic bio-heterojunctions possess the potent antibacterial capacity and effective bacterial eradication.Conclusion:This countermeasure shows great promise for application in infectious wound regeneration.