高尿酸血症与2型糖尿病:从临床视角到分子机制的研究进展

Hyperuricemia and type 2 diabetes mellitus:Studies on recent advances from clinical perspectives to molecular mechanisms

近年来,高尿酸血症(HUA)合并2型糖尿病(T2DM)的发病率逐年上升,笔者综述HUA合并T2DM的临床特征,并探索其可能的分子机制。临床特征包括更容易发生肾功能损害等并发症,死亡风险增加,女性相比男性更易发生HUA合并T2DM,肾旁和肾周脂肪厚度是HUA合并T2DM的危险因素等;可能的分子机制包括遗传突变位点、免疫炎症机制、信号通路等。以新的分子机制为切入点,为HUA合并T2DM的治疗提供新的视角。

In recent years,the incidence rate of hyperuricemia(HUA)combined with type 2 diabetes(T2DM)has increased year by year.This article reviews the clinical characteristics of HUA combined with T2DM and its possible mechanisms.Clinically,HUA combined with T2DM is more prone to complications such as renal function damage and an increased risk of death;it is more likely to develop in women;perirenal and perirenal fat thickness are both risk factors.Its possible molecular mechanisms include genetic mutation sites,immune inflammation mechanisms,signaling pathways,and others.This study provides a new perspective for the treatment of HUA combined with T2DM by using a new molecular mechanism as entry point.