病证结合COPD动物模型研究进展

Research progress of disease⁃syndrome combination models of chronic obstructive pulmonary disease

慢性阻塞性肺疾病(chronic obstructive pulmonary disease, COPD)是临床常见的呼吸系统疾病,发病率高,死亡率高,已成为当今社会一个重要的卫生问题。中医药在COPD的治疗中积累了丰富的历史经验,并且具有独特的临床优势。为深入发掘中医药对本病的治疗效果,制备病证结合的COPD动物模型是关键前提。本文归纳总结的病证结合模型包括肺气虚证动物模型、肺脾两虚证动物模型、痰热郁肺证动物模型、痰瘀阻肺证动物模型、寒饮证动物模型五大类。现将近几年常见的病证结合类造模方法进行简单的阐述与梳理,以期为研究人员提供新思路,推动中医药治疗本病的研究进程。

Chronic obstructive pulmonary disease(COPD)is a common respiratory disease with high morbidity and mortality,and has become a major health issue.Traditional Chinese medicine has accumulated rich historical experience in the treatment of COPD and has unique clinical advantages.To further explore the therapeutic effect of traditional Chinese medicine on this disease,establishment of a COPD animal model combining disease and syndrome is critical to study occurrence and development of the disease.The combined models of disease and syndrome summarized include five types:the animal model of lung qi deficiency,the animal model of lung and spleen deficiency,the animal model of phlegm-heat stagnation of lung,the animal model of phlegm-stasis obstructing lung,and the animal model of cold-fluid syndrome.The common disease and syndrome in recent years combined with the method of class modeling are simply described and combined to provide new ideas for researchers and promote research of traditional Chinese medicine of this disease.