小型猪在中医动物模型中的应用研究进展

Progress in the application of minipigs as animal models of Chinese medicine

中医动物模型是开展中医药研究的实验基础和必备工具。小型猪具有遗传特性稳定、体型小、易繁殖、性格温顺、易饲养、生理生化水平和疾病病理表现与人类相似等特点,是构建实验动物模型的理想选择,在医药领域具有广阔的应用前景及研究价值。目前已有学者利用小型猪构建了虚寒证、血瘀证、实热证、脾气虚证等单纯证候模型;动脉粥样硬化脾虚痰浊证和冠心病痰瘀互结证等中医病证结合模型,均取得较好成果。但目前小型猪在中医动物模型中的应用尚不广泛,值得进一步探索。

Animal models of TCM are the experimental basis and necessary tools to conduct TCM research.Minipigs have stable genetic characteristics,a small size,easy breeding,docile nature,and similar physiology,biochemistry,and disease pathological manifestations to humans,which are ideal to establish experimental animal models and have broad application prospects and research value in the field of medicine.Researchers use small pigs to establish models of simple symptoms such as deficiency cold,blood stasis,actual heat,and spleen Qi deficiency.Models of atherosclerosis with spleen deficiency and phlegm turbidity and coronary heart disease with phlegm and phlegm stasis have achieved good result.However,the application of minipigs as TCM animal models is not widespread and worthy of further exploration.