神经病理性痛等疾病伴发睡眠障碍的特征、机制和治疗研究进展

Progress in characteristics,mechanisms and treatments of secondary sleep disorders associated with neuropathic pain and other diseases

睡眠障碍是指在有条件睡眠的情况下,却出现入睡困难、易觉醒或白天过度睡眠等情况,导致患者正常社会功能受损或引发某些躯体疾病。睡眠障碍发生原因十分复杂,会导致由于各种社会心理因素引发的原发性睡眠障碍,以及其他神经或精神疾病中所出现的继发障碍。本文主要介绍几种常见的继发性睡眠障碍,包括神经病理性痛、情绪障碍类疾病以及神经发育性疾病所引起或伴发的睡眠障碍,对其发病特征、神经机制和现有治疗方法进行阐述,为更深入地开展继发性睡眠障碍疾病的机制研究和治疗干预研究提供指导和帮助。

Sleep disorders refer to the conditions of abnormal sleep which include having difficulty falling asleep,being easy to wake up at night or struggling with excessive sleep during the daytime,resulting in impaired social function or physical diseases.The causes of sleep disorders are very complex,which can lead to primary sleep disorders caused by various psychosocial factors,as well as secondary disorders in other neurological or psychiatric diseases.This paper mainly introduces several common secondary sleep disorders,including those caused by or associated with neuropathic pain,mood disorders,and neurodevelopmental diseases,and elaborates on their pathogenesis,neural mechanism,and current treatments,so as to provide guidance for further research on the mechanism and treatment of secondary sleep disorders.