SphK1/S1P在肿瘤恶性生物学行为中的研究进展

Progress of SphK1/S1P in the biological behavior of tumor malignancy

鞘磷酸激酶1(sphingosin kinase 1,SphK1)是一种鞘磷脂代谢产物的调节因子,催化鞘氨醇转变为鞘氨醇-1-磷酸(sphingosine 1 phosphate acid,S1P)。SphK1/S1P在多种癌症中过表达,本文回顾SphK1/S1P在肿瘤恶性生物学行为如肿瘤细胞增殖、上皮间质转化、获得干细胞样特性、重塑肿瘤微环境、调节肿瘤免疫功能、促进肿瘤细胞远处转移中的作用及机制,表明SphK1/S1P在肿瘤多个恶性生物学行为中起关键作用。

Sphingophosphokinase 1(SphK1)is a regulator of sphingomolipin metabolites that catalyzes the conversion of sphingosine-1-phosphate(S1P)to sphingosine-1-phosphate.SphK1/S1P is overexpressed in a variety of cancers.This paper reviewed the role and mechanism of SphK1/S1P in malignant biological behaviors of tumors,such as tumor cell proliferation,epithelial mesenchymal transformation,acquisition of stem-like properties,remodeling of tumor microenvironment,regulation of tumor immune function,and promotion of distant metastasis of tumor cells.It is suggested that SphK1/S1P plays a key role in multiple malignant biological behaviors of tumors.