不同干预因素建立小鼠动脉粥样硬化模型的研究进展

Research progress on establishment of a mouse atherosclerosis model by various intervention factors

动脉粥样硬化(atherosclerosis, AS)是常见心脑血管疾病的潜在危险因素,严重威胁着人类的健康和生命。AS的防治和抗AS新药的研发是医药学界一直关注的热点。选择理想的AS动物模型是研究AS防治措施及新药研发的关键。理想的AS动物模型应是与人类AS发病机理相似,病理及生化反应一致,且AS模型复制的重复性高、操作简便、易于推广。小鼠具有繁殖性强、遗传性高、可塑性好、AS成模性快等特点,成为了AS研究的理想动物。本文就不同干预因素建立小鼠AS模型的复制方法进行了比较分析,以期为开展AS防治和中药新药研发提供参考和思路。

Atherosclerosis(AS)is a potential risk factor for common cardiovascular and cerebrovascular diseases.Prevention and treatment of AS and research and development of anti-AS drugs have been a focus in the field of medicine.Selection of the ideal AS animal model is important to study prevention and control measures of AS and to research and develop traditional Chinese medicine for AS.The ideal animal model of AS should have similar pathogenesis to human AS,consistent pathological and biochemical reactions,high repeatability,simple operation,and easy adoption.Mice have the characteristics of strong reproduction,high heritability,good plasticity,and fast modeling of AS,and they have become ideal animals for AS research.In this article,the replication method of the mouse AS model established by various intervention factors were compared and analyzed to provide a reference and ideas for prevention and treatment of AS and research and development of traditional Chinese medicine for AS.