丹参提取物治疗增生性瘢痕作用机制研究进展

Research Progress on the Mechanism of Action of Danshen(Salvia Miltiorrhiza)Extracts in the Treatment of Hypertrophic Scar

增生性瘢痕是烧伤、冻伤、手术等创伤造成皮肤深部组织损伤后,修复过程中结缔组织过度增生所致的纤维增生性疾病,不仅影响患者外部美观,还可伴发瘙痒、疼痛及肢体挛缩等症状,严重影响患者的生活质量。目前,增生性瘢痕的形成机制尚未完全明确,多认为与创伤修复过程中细胞因子及相关分子失衡引起的过度炎症反应、成纤维细胞(FB)过度增殖和细胞外基质(ECM)过度沉积有关。近年来,有研究表明,丹参提取物(丹参酮ⅡA、隐丹参酮和丹酚酸B等)可通过抑制促炎细胞活性、抗血管生成、抗FB增殖而发挥抗瘢痕增生作用。基于此,本文从调控炎症反应、抑制FB增殖及血管生成等方面阐述了丹参提取物对增生性瘢痕的影响,以期为丹参在增生性瘢痕中的进一步应用提供理论依据。

Hypertrophic scars are fibro⁃proliferative disorders resulting from hyperplasia of connective tissues during the repair process following deep tissue injury to the skin,such as burns,frostbite,or surgery,which not only affect the aesthetic appearance of patients,but also can lead to symptoms like itching,pain,and limb contracture,significantly impacting their quality of life.Currently,the mechanism underlying the formation of hypertrophic scars remains not fully understood.It is generally believed to be associated with excessive inflammatory responses caused by the imbalance of cytokines and related molecules during the process of wound repair,as well as excessive proliferation of fibroblast(FB)and deposition of the extracellular matrix(ECM).In recent years,some studies have suggested that Danshen extracts(such as DanshinoneⅡA,Cryptotanshinone,and Salvianolic acid B)may suppress scar hyperplasia by inhibiting pro⁃inflammatory cell activity,anti⁃angiogenesis,and anti⁃FB proliferation.Based on this,this article elaborated on the impacts of Danshen extracts on hypertrophic scarring,particularly in the aspects of regulating inflammation,and inhibiting FB proliferation and angiogenesis,to provide a theoretical basis for the further application of Danshen in hypertrophic scars.