玄栀颗粒联合甲巯咪唑治疗甲亢的临床观察

Clinical Observation of Xuanzhi Granule Combined with Methimazole in the Treatment of Hyperthyroidism

目的观察玄栀颗粒联合甲巯咪唑治疗甲状腺功能亢进症(甲亢)的临床疗效。方法用随机数字法将72例甲亢患者分为治疗组和对照组,每组36例。对照组予以甲巯咪唑治疗,治疗组在此基础上联合玄栀颗粒治疗,分别在治疗前后观察甲状腺功能、肝功能水平和焦虑自评量表(SAS)评分。结果治疗组总有效率97.22%高于对照组88.89%,(P<0.05);与治疗前相比,2组治疗后促甲状腺激素(TSH)水平均较前提高(P<0.05),SAS评分、游离三碘甲状腺原氨酸(FT3)及游离四碘甲状腺原氨酸(FT4)水平均较前降低(P<0.05);而对照组肝功能指标水平较前升高(P<0.05),治疗组则变化无差异;与对照组相比,治疗组TSH水平提高(P<0.05),而FT4、FT3及肝功能指标水平降低(P<0.05)。结论玄栀颗粒联合甲巯咪唑治疗可有效改善甲亢患者的甲状腺激素水平,减少肝功能损伤,改善焦虑状态,提升治疗的整体效果,对甲亢的整体治疗具有一定意义。

Objective:To observe the clinical effect of Xuanzhi Granule combined with methimazole in the treatment of hyperthyroidism.Methods:72 hyperthyroidism patients were divided into treatment group and control group by random number method,36 cases each group.The control group was treated with methimazole and the treatment group was added Xuanzhi Granule on the basis of the control group.The thyroid function,liver function and self-rating anxiety scale(SAS)scores of the two groups were observed before and after treatment.Results:The total effective rate of the treatment group 97.22%was higher than that of the control group 88.89%(P<0.05).Compared with that of the prior treatment,the level of thyrotropin(TSH)in the two groups after treatment were higher than before(P<0.05),and the levels of SAS score,free triiodothyronine(FT3)and free tetraiodothyronine(FT4)were lower than before(P<0.05).The level of liver function index in the control group was higher than before(P<0.05),but there was no difference in the treatment group.Compared with that in the control group,TSH level in the treatment group was increased(P<0.05),while FT4,FT3 and liver function index levels were decreased(P<0.05).Conclusion:Xuanzhi Granule combined with methimazole can effectively improve the thyroid hormone level in hyperthyroidism patients,reduce liver function injury,improve anxiety state,and enhance the overall effect of treatment,and has a certain significance for the overall treatment of hyperthyroidism.