根治性肝切除术肝细胞癌患者预后预测模型研究进展

Research Progress on Prognostic Prediction Models After Radical Resection of Hepatocellular Carcinoma

Child-Pugh分级和终末期肝病模型是术前评估肝细胞癌(hepatocellular carcinoma, HCC)患者根治性肝切除术后肝功能衰竭及整体临床转归的经典方法,但受白蛋白、腹水、血肌酐等因素的影响,二者的应用存在一定局限性。查阅国内外相关文献后发现,术前白蛋白-胆红素评分、血小板-白蛋白-胆红素评分、格拉斯哥预后评分以及新型预测模型在HCC患者肝切除术后肝功能衰竭及临床预后评估中具有良好的应用前景。本文将对常用的根治性肝切除术HCC患者预后模型进行介绍,并对其应用价值进行综述。

The classical Child-Pugh classification and the model for end-stage liver disease are now widely used in clinics for postoperative assessment of liver failure and prognosis in patients with hepatocellular carcinoma(HCC)treated with radical hepatectomy.However,there are limitations in the application of both methods due to factors such as albumin,ascites,and blood creatinine.A review of the relevant literature at home and abroad revealed that preoperative albumin bilirubin score,platelet albumin bilirubin score,Glasgow prognostic score and new predictive models have good application prospects in evaluating liver failure and prog-nosis of HCC patients after hepatectomy.In this paper,we aim to introduce the commonly used prognostic mod-els for HCC patients undergoing radical hepatectomy and review the value of their application.