甲亢孕妇血清25-羟维生素D、血钙及骨钙素水平与新生儿骨密度不足的相关性分析

Correlation between serum 25-hydroxyvitamin D,serum calcium and osteocalcin levels in pregnant women with hyperthyroidism and neonatal bone mineral density deficiency

目的探究甲亢孕妇血清25-羟维生素D、血钙及骨钙素水平与其所娩新生儿骨密度不足的相关性。方法选取2017年3月—2022年6月在本院产检并分娩的86例甲亢孕产妇(观察组)及其新生儿和83例正常分娩孕妇(对照组)及其新生儿为研究对象。收集2组产妇一般资料;检测新生儿出生第3天的骨密度情况;对甲亢孕妇一般资料与临床指标及其所娩新生儿骨密度不足进行单因素分析和logistic回归分析;进行甲亢孕妇血清25-羟维生素D、血钙及骨钙素与新生儿骨密度不足的Spearman相关性分析。结果观察组所娩新生儿骨密度不足发生率为30.23%(26/86),显著高于对照组的4.82%(4/83),差异有统计学意义(P<0.05);单因素分析结果显示,骨密度不足新生儿母亲血钙及骨钙素水平显著高于骨密度正常新生儿母亲,血清25-羟维生素D水平显著低于骨密度正常新生儿母亲(P<0.05);logistic回归分析结果显示,血钙、骨钙素水平升高,25-羟维生素D水平降低是甲亢孕产妇所娩新生儿骨密度不足的独立影响因素(P<0.05)。结论甲亢孕妇所娩新生儿骨密度不足与25-羟维生素D成负相关,与血钙及骨钙素水平成正相关。

Objective This paper aims to explore the correlation of serum 25-hydroxyvitamin D,serum calcium and osteocalcin levels in pregnant women with hyperthyroidism and their newborns with insufficient bone mineral density.Methods A total of 86 pregnant women with hyperthyroidism(observation group)and their neonates who underwent obstetric examination and delivery in our hospital from March 2017 to June 2022,and 83 normal delivery pregnant women(control group)and their neonates were selected as the research objects.The general data of the two groups of puerpera were collected;the bone mineral density of newborns on the third day of birth was detected;the general data and clinical indicators of pregnant women with hyperthyroidism and the bone mineral density of their newborns were subjected to univariate analysis and logistic regression analysis.The correlation between serum 25-hydroxyvitamin D,serum calcium and osteocalcin in hyperthyroid pregnant women and neonatal bone mineral density deficiency was analyzed by Spearman.Results The insufficiency incidence of bone mineral density in neonates born in the observation group was 30.23%(26/86),which was significantly higher than that in the control group(4.82%,4/83),and the difference was statistically significant(P<0.05).Univariate analysis showed that the serum calcium and osteocalcin levels of neonatal mothers with low bone mineral density were significantly higher than those of neonatal mothers with normal bone mineral density,and the serum 25-hydroxyvitamin D levels were significantly lower than those of neonatal mothers with normal bone mineral density(P<0.05).Logistic regression analysis showed that the increase of serum calcium and osteocalcin levels and the decrease of 25-hydroxyvitamin D levels were independent influencing factors for neonatal bone mineral density deficiency in hyperthyroid women-delivered infants(P<0.05).Conclusion Insufficiency of bone mineral density in neonates born to pregnant women with hyperthyroidism is negatively correlated with 25-hydroxyvitamin D and positively correlated with serum calcium and osteocalcin levels.