量化式目标锻炼联合全程精细化营养管理在血液病化疗患者中的应用效果

Application of quantitative goal exercise combined with whole process refined nutrition management in patients with hematological disease chemotherapy

目的探讨量化式目标锻炼(QGE)联合全程精细化营养管理(WP-RNM)对血液病化疗患者临床效果的影响,为提高血液病患者化疗后康复管理质量提供依据。方法选取空军军医大学第一附属医院2019年2月-2021年6月收治的血液病化疗患者126例,采用随机数表法分为观察组和对照组各63例。对照组采用常规干预,观察组在常规干预的基础上加用QGE联合WP-RNM干预方案。比较2组干预前后的营养状况、免疫功能及生活质量变化。结果观察组干预后血红蛋白(Hb)、血浆前白蛋白(PAB)、白蛋白(ALB)、转铁蛋白(TRF)均明显高于对照组(均P<0.001),主观整体营养状况评估量表(PG-SGA)评分明显低于对照组[(1.92±0.72)分vs.(4.26±0.81)分,t=17.138,P<0.01];观察组干预后肿瘤患者生活质量自评量表-30(QLQ-C30)各评分均明显低于对照组(均P<0.001);观察组干预后血清IgG抗体(IgG)、IgA抗体(IgA)、IgM抗体(IgM)、CD3+T细胞百分比、CD4+T细胞百分比均明显高于对照组(t=28.857、6.683、9.191、20.013、12.798,均P<0.01)。结论QGE联合WP-RNM能有效提高血液病化疗患者的营养摄入量和免疫功能,改善患者的生活质量。

Objective To explore the effect of quantitative targeted exercise(QGE)combined with whole process refined nutrition management(WP-RNM)on the clinical results of patients with hematologic diseases undergoing chemotherapy,and to provide evidence for improving the quality of rehabilitation management of patients with hematologic diseases after chemotherapy.Methods A total of 126 patients with hematologic diseases treated with chemotherapy in First Affiliated Hospital of Air Force Military Medical University from February 2019 to June 2021 were selected and randomly divided into observation group and control group with 63 patients in each group by random number table sampling method.The control group was treated with routine intervention,and the observation group was treated with QGE combined WP-RNM intervention program on the basis of routine intervention.The nutritional status,immune function and life quality of the two groups were compared before and after intervention.Result After intervention,the scores of hemoglobin(Hb),plasma prealbumin(PAB),albumin(Alb),transferrin(TRF)and scored patient-generated subjective global assessment(PG-SGA)in the observation group were significantly higher than those in the control group(all P<0.001).The PG-SGA score was significantly lower than that of the control group[(1.92±0.72)points vs.(4.26±0.81)points,t=17.138,P<0.01].After intervention,the scores of quality of life questionnaire-C30(QLQ-C30)in the observation group were significantly lower than those in the control group(all P<0.001).After intervention,serum IgG antibody(IgG),IgA antibody(IgA),IgM antibody(IgM),percentage of CD3+T cells and CD4+T cells in the observation group were significantly higher than those in the control group(t-values:28.857,6.683,9.191,20.013 and 12.798,respectively,all P<0.01).Conclusion QGE combined with WP-RNM can effectively improve the nutritional intake and immune function of patients with hematological diseases and improve the quality of life of patients.