补阳还五汤合升降散治疗糖尿病肾病临床观察

Buyang Huanwu Decoction Combined with Shengjiang Powder in the Treatment of Diabetic Kidney Disease

目的观察补阳还五汤合升降散加减对Ⅲ、Ⅳ期糖尿病肾病(DKD)的治疗效果,为临床实践提供理论依据。方法将80例DKD患者随机分为2组,治疗组采用补阳还五汤合升降散加减治疗,对照组给予盐酸贝那普利片治疗。治疗12周后,观察治疗前后2组中医临床症状积分、血糖、肾功能、24 h尿蛋白定量等的变化。结果对于Ⅲ、Ⅳ期DKD患者,治疗12周后,治疗组中医临床症状积分、血糖、肾功能、24 h尿蛋白定量等均较对照组改善明显(P<0.05)。结论补阳还五汤合升降散加减治疗DKD效果满意,可以更好地降低尿蛋白、延缓DKD进程、改善生活质量。

Objective To observe clinical effects of Buyang Huanwu decoction combined with Shengjiang powder in the treatment of stage Ⅲ and Ⅳ of diabetic kidney disease(DKD)and to provide a theoretical basis for clinical practice.Methods All 80 patients were randomized into two groups,with 40 cases each group.The control group adopted the therapy of benazepril and the observation group took Buyang Huanwu decoction combined with Shengjiang powder orally on the foundation of Western medicine for twelve consecutive weeks.The changes of clinical symptom integral,blood glucose,renal function,and 24h urinary protein quantification in the two groups were observed before and after treatment.Results For patients with stage Ⅲ and Ⅳ of DKD,after 12 weeks of treatment,the symptom score,blood glucose,renal function and urinary protein quantification in the treatment group were significantly improved compared with the treatment group(P<0.05).Conclusion Buyang Huanwu decoction combined with Shengjiang powder in the treatment of DKD can better reduce the urinary protein,delay the DKD process,and improve the quality of life.