儿童青少年佩戴角膜塑形镜后不同时间点脉络膜厚度变化的Meta分析

Meta-analysis of choroidal thickness changes at different time points in children and adolescents after wearing orthokeratology Lenses

目的评价儿童青少年佩戴角膜塑形镜(orthokeratology;OK)后脉络膜厚度(Choroid Thickness,ChT)的变化,分析其与近视的相关性。方法在PubMed、Embase、VIP、万方、知网等数据库检索自建库以来至2023年5月有关佩戴OK镜后ChT变化的文献。文献筛选与数据资料提取由两位成员完成,使用Revman 5.3软件进行Meta分析。结果纳入10篇文献,含括649个样本。统计分析显示:ChT在戴镜后1wk较戴镜前增加,差异具统计学意义[MD=10.81,95%CI(7.60~14.02),P<0.01]。戴镜后1m较戴镜后1wk,ChT增加,差异有统计学意义[MD=10.84,95%CI(7.49~14.19),P<0.01]。戴镜后1m至1y范围内,ChT变化无统计学意义(P>0.05)。结论佩戴OK镜后的1m内ChT呈现持续增厚,1m-1y内ChT趋向稳定。

Objective To evaluate choroidal thickness changes after wearing orthokeratology lenses in children and adolescents,and to analyze the correlation between choroidal thickness change and myopia.Methods Use PubMed,Embase,VIP,WanFang Data,and CNKI databases to search the literature on ChT changes after wearing orthokeratology lenses from the establishment of the library to May 2023.Two researchers and meta-analyses performed literature screening and data extraction using Review Manager 5.3.Results Ten articles containing 649 samples were included.The statistical analysis results showed that ChT increased by 1 wk after wearing glasses compared with before wearing glasses,and the difference was statistically significant[1wk:MD=10.81,95%CI(7.60~14.02),P<0.01].Compared with 1wk ChT after wearing glasses,the ChT of 1m increased,and the difference was statistically significant[MD=10.84,95%CI(7.49~14.19),P<0.01].In the range of 1m-1y after wearing orthokeratology lenses,There was no significant increase in choroid thickness(P>0.05).Conclusion The ChT continued to thicken within 1m after wearing,and the ChT tended to be stable in 1 month to 1 year after wearing.